Tsunade is a supporting character in the anime and manga series Naruto. She took over the direction of Konohagakure after Hiruzen Sarutobi died, thus becoming the Fifth and present Hokage. Along with Orochimaru and Jiraiya, she is one of the Legendary Sannin of Konoha, and currently the only one still alive after Jiraiya’s death and Orochimaru permanently sealed. She excels in medical ninjutsu.

The Hokage is the leader of Konohagakure. Over the course of the series, there have been five Hokage, who are honored by the village by having sculptures of their faces carved into the rock formation overlooking Konohagakure. The First Hokage was Hashirama Senju ,who founded the village along with Madara Uchiha. With his unique Mokuton abilities, he created the trees that act as the foundation for Konohagakure, and his method of rule became a model for all subsequent Hokage.

The First was succeeded by his younger brother, Tobirama Senju , who became the Second Hokage. He in turn was followed by one of his students, who became the Third Hokage. After a long rule, the Third abdicated in favor of Minato Namikaze, who took the position of Fourth Hokage, but reclaimed his position after the Fourth gave his life to save the village from the nine-tailed demon fox. The Third is the Hokage at the beginning of the series, but he is slain in battle by his former student, Orochimaru, during an invasion of Konohagakure by Sunagakure and Otogakure. Another of his students, Tsunade, succeeds him as the Fifth Hokage